insulin resistance

noun

: reduced sensitivity to insulin by the body's insulin-dependent processes (such as glucose uptake and lipolysis) that is typical of type 2 diabetes but often occurs in the absence of diabetes

Examples of insulin resistance in a Sentence

Recent Examples on the Web
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People with insulin resistance, such as people with type 2 diabetes or metabolic syndrome, may experience higher blood sugar spikes compared to others. Kathleen Ferraro, Verywell Health, 20 May 2026 Researchers say that framing better captures what patients actually experience, from insulin resistance and elevated androgens to irregular periods, acne, weight changes and infertility. Samantha Agate, Charlotte Observer, 19 May 2026 On the metabolic side, patients might develop insulin resistance, weight gain, difficulty with weight loss and dark velvety skin patches around the neck or armpits, as well as significantly elevated risk of prediabetes, type 2 diabetes and cardiovascular disease. Adaira Landry, Forbes.com, 15 May 2026 For someone bothered by acne, hair growth, irregular bleeding, weight gain, or insulin resistance, the plan may look different. Michelle Seguin, EverydayHealth.com, 13 May 2026 See All Example Sentences for insulin resistance

Word History

First Known Use

1927, in the meaning defined above

Time Traveler
The first known use of insulin resistance was in 1927

Cite this Entry

“Insulin resistance.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/insulin%20resistance. Accessed 24 May. 2026.

Medical Definition

insulin resistance

noun
: reduced sensitivity to insulin by the body's insulin-dependent processes (as glucose uptake, lipolysis, and inhibition of glucose production by the liver) that results in decreased activity of these processes or an increase in insulin production or both and that is typical of type 2 diabetes but often occurs in the absence of diabetes
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